Poster abstracts
Poster number 137 submitted by Devlin Moyer
The Intron Annotation and Orthology Database (IAOD)
Devlin C. Moyer (Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner College of Medicine, School of Medicine, Case Western Reserve University), Graham Larue (Department of Biology, San Francisco State University), Courtney E. Hershberger (Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner College of Medicine, School of Medicine, Case Western Reserve University), Scott W. Roy (Department of Biology, San Francisco State University), Richard A. Padgett (Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner College of Medicine, School of Medicine, Case Western Reserve University)
Abstract:
During maturation of nearly all eukaryotic messenger RNAs and long non-coding RNAs, sequences called introns are removed in the process of RNA splicing. Two complexes of proteins and small nuclear ribonucleoprotein particles—the U2- and U12-dependent spliceosomes—are responsible for excising introns. Regulation of splicing has played an important role in eukaryotic evolution and is crucial to the etiologies of many human diseases. Many databases of intron annotation information have been created, but few remain accessible. Very few databases have ever annotated U12-dependent introns, and those that do have major limitations that restrict their relevance to many pursuits. The Intron Annotation and Orthology Database (IAOD) is a comprehensive database of intron annotation information in 24 evolutionarily diverse organisms. The website and database are both entirely open-source, and it has been specifically designed to be simple to update, so that it can be a useful genomics resource for many years. We believe that IAOD will be a valuable tool for many inquiries into the evolutionary history of introns.
Keywords: introns, alternative splicing, comparative genomics