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Friday, Oct 27

09:00-12:00pmOptional workshops, rooms 103AB and 104AB Kellogg Center
11:00-04:30pmMeeting registration, Kellogg Center South Lobby

Session I: Structure, Dynamics, and Function
Session Chair: Chase Weidmann, University of Michigan

01:00-01:15pmWelcome and Introductions
01:15-01:30pmDual conformational states of HIV-1 RRE stem-loop II and implications for the initial high-affinity Rev interaction
Jerricho Tipo, Keerthi Gottipati, Kay Choi
Department of Molecular and Cellular Biochemistry, Indiana University
01:30-01:45pmA novel reagent for mutational profiling of RNA in vivo
Catherine A. Douds, Paul Babitzke, Philip C. Bevilacqua
BMMB Department Pennsylvania State University
01:45-02:00pmGlobal RNA modifications to the MALAT1 triple helix affect thermostability and weaken binding to METTL16
Mika Schievelbein, Carlos Resende, Madeline M. Glennon, Jessica A. Brown
Department of Chemistry and Biochemistry, University of Notre Dame
02:00-02:15pmThe role of transcriptional start site heterogeneity in the translation of HIV-1 genomic RNA
Joseph G. Kanlong, Zetao Cheng, Saiful Islam, Olga A. Nikolaitchik, Wei-Shau Hu, Vinay K. Pathak, Michael G. Kearse, Christina R. Budding, Heewon Seo, Karin Musier-Forsyth
Department of Chemistry and Biochemistry, Center for RNA Biology, Center for Retrovirus Research, The Ohio State University, Columbus, OH
02:15-02:30pmRNA-driven Percolation Transitions in Aging Biomolecular Condensates
Tharun Selvam Mahendran, Gable M. Wadsworth , Priya R. Banerjee
Department of Biology, SUNY Buffalo
02:30-02:45pmBacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P
Catherine Wilhelm, Leena Mallik, Abigail L. Kelly, Shayna B. Brotzman, Johnny Mendoza, Anna G. Anders, Suada Leskaj, Carmen Castillo, Michael Cianfrocco, Brandon T. Ruotolo, Markos Koutmos
Department of Chemistry at the University of Michigan

Session II: RNA Regulation and Regulation by RNA
Session Chair: Janie Frandsen, Gustavus Adolphus College

02:45-03:15pmCoffee Break
03:15-03:30pmNusG-dependent RNA polymerase pausing is a common component of riboswitch regulatory mechanisms
Oshadhi T. Jayasinghe, Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke
Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802
03:30-03:45pmMechanics of divalent ion sensitivity of the manganese-sensing riboswitch measured by combined high-resolution optical tweezers and single-molecule fluorescence
Rajeev Yadav, Shankar Mandal, Shiba S Dandpat, Nils G Walter, Matthew J Comstock
Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824, USA.
03:45-04:00pmUnraveling Cell-Type-Specific Alternative Cleavage and Polyadenylation Regulatory Mechanisms Governed by CLP1
Jingyi Liu, Ashleigh E. Schaffer
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
04:00-04:15pmLigand and transcription factor NusA differentially modulate 30S subunit recruitment by a translational riboswitch-controlled mRNA
Elizabeth A. Franklin, Adrien Chauvier, Nils G. Walter
Department of Chemistry, University of Michigan Ann Arbor
04:15-04:30pmIdentification of RNA-binding proteins’ direct effects on gene expression via the degradation tag system
Kailey Worner, Qiuying Liu, Katharine Maschhoff, Wenqian Hu
Biochemistry & Molecular Biology, Mayo Clinic
04:30-04:45pmBrief meeting for p.i.s Please remain in the session room
04:30-05:00pmCoffee Break
05:00-06:00pmKEYNOTE LECTURE
Viral RNAs that bind and manipulate the ribosome
Dr. Jeffrey Kieft, New York Structural Biology Center
06:15-08:00pmDinner, Big Ten Room BC
08:00-11:00pmPoster session and reception, Red Cedar and Centennial rooms
Odd-numbered posters on display 800 - 915
Even-numbered posters on display 915 - 1030
08:00-10:30pmCash Bar, Galaxy Room

Saturday, Oct 28

07:30-08:30amBuffet Breakfast, Big Ten Room BC

Session III: RNA in Disease and Development
Session Chair: Brittany Morgan, University of Notre Dame

08:45-09:00amExamining the therapeutic effects of splice-switching oligonucleotides for insulin receptor in osteosarcoma.
Akila S. Venkataramany, Safiya Khurshid, PhD, Matias Montes, PhD, Pin-Yi Wang, PhD, Timothy P. Cripe, MD PhD, Dawn S. Chandler, PhD
Medical Scientist Training Program and Biomedical Sciences Training Program, OSUCOM; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Childrens Hospital
09:00-09:15amDepletion of eIF4E1 drives Toxoplasma gondii parasite stage differentiation and latency
Michael J Holmes, Matheus S Bastos, Vishakha Dey, Vanessa Severo, Ronald C Wek, William J Sullivan Jr
Pharmacology & Toxicology, IU School of Medicine
09:15-09:30amSmall Circular mRNA Vaccines for Tumor Immunotherapy
Xiang Liu, Yu Zhang, Guizhi Zhu
Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan.
09:30-09:45amParkinson's Disease associated genes are directly regulated by Pumilio proteins
Pavithra S. Madamarandawala, Wendy M. Olivas
Department of Biology, University of Missouri-St. Louis
09:45-10:00amThe cellular morphologies of cancer-related DDX3X mutants are defined by their catalytic activities
Michael C. Owens, Hui Shen, Amber Yanas, Maria Saraí Mendoza-Figueroa, Ellen Lavorando, Xiaoyu Wei, Yale E. Goldman, Kathy Fange Liu
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA
10:00-10:30amCoffee Break

Session IV: RNA Processing, Translation, and Decay
Session Chair: Chris Rohlman, Albion College

10:30-10:45amLoss of tRNA synthetase activity breaks an RNA cycle during stress
Max Baymiller, Stephanie L. Moon
Human Genetics, University of Michigan
10:45-11:00amRole of the sarcin-ricin loop (SRL) of 23S rRNA in assembly of the 50S ribosomal subunit
Sepideh Fakhretaha Aval, Kyung-Mee Moon, Leonard J Foster , Kurt Fredrick
Ohio state Biochemistry program, Department of Microbiology, The Ohio State University
11:00-11:15amPARP1 inhibition at R loops selectively kills spliceosome mutant leukemias by triggering transcription-replication conflicts.
Zhiyan Silvia Liu, Sayantani Sinha, Axia Song, Erica Arriaga-Gomez, Elizabeth Bonner, Maxwell Bannister, Alexander McKeeken, Benjamin Hanson, Dawei Zong, Victor Corral, Jennifer Yoo, Wannasiri Chiraphapphaiboon, Cassandra Leibson, Evan Nguyen, Stanley C Lee, Matthew McMahon, Hai Dang Nguyen
Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA
11:15-11:30amInvestigating the interactome and functions of the UPF3 paralogs in Nonsense Mediated Decay
Rene Arvola, Kristen Nedza, Guramrit Singh
Department of Molecular Genetics, The Ohio State University; Center for RNA Biology, The Ohio State University
11:30-11:45amLong non-coding RNA MALAT1 regulates hypoxia-responsive alternative splicing by acting as a RNA-binding protein scaffold
You Jin Song, Sushant Bangru, Yu Wang, Andrew Belmont, Auinash Kalsotra, Prasanth Kannanganattu
Department of Cell and Developmental Biology, UIUC
11:45-12:00pmAct1 propels chemoresistance by modulating redox homeostasis via epitranscriptomic regulation of antioxidant RNA metabolism
Lingzi Hong, Tomasz Herjan, Xiao Li
Immunity and Inflammation, Cleveland and clinic
12:00-12:15pmPseudouridine Synthase 7 localization influences mRNA modification landscape and stress tolerance
Minli Ruan, Kristin S. Koutmou
University of Michigan, Department of Biological Chemistry
12:15-12:35pmCircular RNAs: an underdog of HIV diagnostics
Jian Shi, Megan L. Van Horn, Marta Rachwalak, Anna M. Kietrys
Chemistry Department, Carnegie Mellon University
12:35-12:55pmStructural biology paired with in silico screening to predict RNA modification-protein interactions
Murphy Angelo, Wen Zhang, Jonah Z. Vilseck, Scott T. Aoki
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana
12:55-01:30pmPresentation awards and meeting close