Agenda
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Friday, Oct 27
| Time | Event |
|---|---|
| 09:00-12:00pm | Optional workshops, rooms 103AB and 104AB Kellogg Center |
| 11:00-04:30pm | Meeting registration, Kellogg Center South Lobby |
Session I: Structure, Dynamics, and Function | |
| 01:00-01:15pm | Welcome and Introductions |
| 01:15-01:30pm | Dual conformational states of HIV-1 RRE stem-loop II and implications for the initial high-affinity Rev interaction Jerricho Tipo, Keerthi Gottipati, Kay Choi Department of Molecular and Cellular Biochemistry, Indiana University |
| 01:30-01:45pm | A novel reagent for mutational profiling of RNA in vivo Catherine A. Douds, Paul Babitzke, Philip C. Bevilacqua BMMB Department Pennsylvania State University |
| 01:45-02:00pm | Global RNA modifications to the MALAT1 triple helix affect thermostability and weaken binding to METTL16 Mika Schievelbein, Carlos Resende, Madeline M. Glennon, Jessica A. Brown Department of Chemistry and Biochemistry, University of Notre Dame |
| 02:00-02:15pm | The role of transcriptional start site heterogeneity in the translation of HIV-1 genomic RNA Joseph G. Kanlong, Zetao Cheng, Saiful Islam, Olga A. Nikolaitchik, Wei-Shau Hu, Vinay K. Pathak, Michael G. Kearse, Christina R. Budding, Heewon Seo, Karin Musier-Forsyth Department of Chemistry and Biochemistry, Center for RNA Biology, Center for Retrovirus Research, The Ohio State University, Columbus, OH |
| 02:15-02:30pm | RNA-driven Percolation Transitions in Aging Biomolecular Condensates Tharun Selvam Mahendran, Gable M. Wadsworth , Priya R. Banerjee Department of Biology, SUNY Buffalo |
| 02:30-02:45pm | Bacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P Catherine Wilhelm, Leena Mallik, Abigail L. Kelly, Shayna B. Brotzman, Johnny Mendoza, Anna G. Anders, Suada Leskaj, Carmen Castillo, Michael Cianfrocco, Brandon T. Ruotolo, Markos Koutmos Department of Chemistry at the University of Michigan |
Session II: RNA Regulation and Regulation by RNA | |
| 02:45-03:15pm | Coffee Break |
| 03:15-03:30pm | NusG-dependent RNA polymerase pausing is a common component of riboswitch regulatory mechanisms Oshadhi T. Jayasinghe, Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802 |
| 03:30-03:45pm | Mechanics of divalent ion sensitivity of the manganese-sensing riboswitch measured by combined high-resolution optical tweezers and single-molecule fluorescence Rajeev Yadav, Shankar Mandal, Shiba S Dandpat, Nils G Walter, Matthew J Comstock Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824, USA. |
| 03:45-04:00pm | Unraveling Cell-Type-Specific Alternative Cleavage and Polyadenylation Regulatory Mechanisms Governed by CLP1 Jingyi Liu, Ashleigh E. Schaffer Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine |
| 04:00-04:15pm | Ligand and transcription factor NusA differentially modulate 30S subunit recruitment by a translational riboswitch-controlled mRNA Elizabeth A. Franklin, Adrien Chauvier, Nils G. Walter Department of Chemistry, University of Michigan Ann Arbor |
| 04:15-04:30pm | Identification of RNA-binding proteins’ direct effects on gene expression via the degradation tag system Kailey Worner, Qiuying Liu, Katharine Maschhoff, Wenqian Hu Biochemistry & Molecular Biology, Mayo Clinic |
| 04:30-04:45pm | Brief meeting for p.i.s Please remain in the session room |
| 04:30-05:00pm | Coffee Break |
| 05:00-06:00pm | KEYNOTE LECTURE Viral RNAs that bind and manipulate the ribosome Dr. Jeffrey Kieft, New York Structural Biology Center |
| 06:15-08:00pm | Dinner, Big Ten Room BC |
| 08:00-11:00pm | Poster session and reception, Red Cedar and Centennial rooms Odd-numbered posters on display 800 - 915 Even-numbered posters on display 915 - 1030 |
| 08:00-10:30pm | Cash Bar, Galaxy Room |
Saturday, Oct 28
| Time | Event |
|---|---|
| 07:30-08:30am | Buffet Breakfast, Big Ten Room BC |
Session III: RNA in Disease and Development | |
| 08:45-09:00am | Examining the therapeutic effects of splice-switching oligonucleotides for insulin receptor in osteosarcoma. Akila S. Venkataramany, Safiya Khurshid, PhD, Matias Montes, PhD, Pin-Yi Wang, PhD, Timothy P. Cripe, MD PhD, Dawn S. Chandler, PhD Medical Scientist Training Program and Biomedical Sciences Training Program, OSUCOM; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Childrens Hospital |
| 09:00-09:15am | Depletion of eIF4E1 drives Toxoplasma gondii parasite stage differentiation and latency Michael J Holmes, Matheus S Bastos, Vishakha Dey, Vanessa Severo, Ronald C Wek, William J Sullivan Jr Pharmacology & Toxicology, IU School of Medicine |
| 09:15-09:30am | Small Circular mRNA Vaccines for Tumor Immunotherapy Xiang Liu, Yu Zhang, Guizhi Zhu Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan. |
| 09:30-09:45am | Parkinson's Disease associated genes are directly regulated by Pumilio proteins Pavithra S. Madamarandawala, Wendy M. Olivas Department of Biology, University of Missouri-St. Louis |
| 09:45-10:00am | The cellular morphologies of cancer-related DDX3X mutants are defined by their catalytic activities Michael C. Owens, Hui Shen, Amber Yanas, Maria Saraí Mendoza-Figueroa, Ellen Lavorando, Xiaoyu Wei, Yale E. Goldman, Kathy Fange Liu Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA |
| 10:00-10:30am | Coffee Break |
Session IV: RNA Processing, Translation, and Decay | |
| 10:30-10:45am | Loss of tRNA synthetase activity breaks an RNA cycle during stress Max Baymiller, Stephanie L. Moon Human Genetics, University of Michigan |
| 10:45-11:00am | Role of the sarcin-ricin loop (SRL) of 23S rRNA in assembly of the 50S ribosomal subunit Sepideh Fakhretaha Aval, Kyung-Mee Moon, Leonard J Foster , Kurt Fredrick Ohio state Biochemistry program, Department of Microbiology, The Ohio State University |
| 11:00-11:15am | PARP1 inhibition at R loops selectively kills spliceosome mutant leukemias by triggering transcription-replication conflicts. Zhiyan Silvia Liu, Sayantani Sinha, Axia Song, Erica Arriaga-Gomez, Elizabeth Bonner, Maxwell Bannister, Alexander McKeeken, Benjamin Hanson, Dawei Zong, Victor Corral, Jennifer Yoo, Wannasiri Chiraphapphaiboon, Cassandra Leibson, Evan Nguyen, Stanley C Lee, Matthew McMahon, Hai Dang Nguyen Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA |
| 11:15-11:30am | Investigating the interactome and functions of the UPF3 paralogs in Nonsense Mediated Decay Rene Arvola, Kristen Nedza, Guramrit Singh Department of Molecular Genetics, The Ohio State University; Center for RNA Biology, The Ohio State University |
| 11:30-11:45am | Long non-coding RNA MALAT1 regulates hypoxia-responsive alternative splicing by acting as a RNA-binding protein scaffold You Jin Song, Sushant Bangru, Yu Wang, Andrew Belmont, Auinash Kalsotra, Prasanth Kannanganattu Department of Cell and Developmental Biology, UIUC |
| 11:45-12:00pm | Act1 propels chemoresistance by modulating redox homeostasis via epitranscriptomic regulation of antioxidant RNA metabolism Lingzi Hong, Tomasz Herjan, Xiao Li Immunity and Inflammation, Cleveland and clinic |
| 12:00-12:15pm | Pseudouridine Synthase 7 localization influences mRNA modification landscape and stress tolerance Minli Ruan, Kristin S. Koutmou University of Michigan, Department of Biological Chemistry |
| 12:15-12:35pm | Circular RNAs: an underdog of HIV diagnostics Jian Shi, Megan L. Van Horn, Marta Rachwalak, Anna M. Kietrys Chemistry Department, Carnegie Mellon University |
| 12:35-12:55pm | Structural biology paired with in silico screening to predict RNA modification-protein interactions Murphy Angelo, Wen Zhang, Jonah Z. Vilseck, Scott T. Aoki Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana |
| 12:55-01:30pm | Presentation awards and meeting close |