Agenda
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Friday, Oct 30
| Time | Event |
|---|---|
| 09:00-12:00pm | Trainee workshops 1 & 2 (registration required) |
| 01:00-01:15pm | Welcome and introductory remarks |
Session I: tRNA & RNA Modification/Processing (chaired by Dr. Anna Kietrys) | |
| 01:15-01:30pm | T-sncR-seq allows for robust detection of transfer RNAs and other small noncoding RNAs at single cell resolution Anthony Caputo, Ashleigh Schaffer, Thomas J. Sweet Case Western Reserve University School of Medicine, Department of Genetics and Genome Sciences, Cleveland, Ohio, United States |
| 01:30-01:45pm | Structure, binding and activity of the human tRNA modification enzyme TRIT1 with tRNA-Sec Elizaveta Karchuganova, Daniel J. Corey, Markos Koutmos Department of Chemistry, University of Michigan |
| 01:45-02:00pm | Discovering the hidden potential of 3-5 polymerases: high-throughput substrate specificities of Thg1-like proteins Thaanya Amarasekara, Malithi Ishara Jayasinghe, Ryan Denniston, Jane E. Jackman Department of Chemistry and Biochemistry, Center for RNA biology, The Ohio State Biochemistry Program, The Ohio State University |
| 02:00-02:15pm | Computational modeling illuminates structural changes caused by a neurodegeneration-associated C50U mutation in a tRNA-Arg-UCU isodecoder Danielle Wampler, Rachel M. Robertson, Ehsan Akbari, Michael G. Poirier, Venkat Gopalan, Ralf Bundschuh Depatrment of Physics, The Ohio State University |
| 02:15-02:30pm | Substrate recognition and catalysis by TOE1: biochemical and structural insights into snRNA 3-end maturation Lizette Zavala, Cassandra Hayne Biochemistry and Molecular Biology, University of Chicago |
| 02:30-02:45pm | Cellular signal-responsive m5C editing by an inducible split CRISPR platform Chanjuan Dong, Ying, Xu, Kellie, Wu, Nathan Mu, Satendra, Kumar department of chemistry, Case Western Reserve University |
| 02:45-03:15pm | Coffee break |
| 02:45-03:15pm | PI meeting |
Session II: Translational Control & Small RNAs (chaired by Dr. Agnes Karasik) | |
| 03:15-03:30pm | A uORF-encoded micropeptide provides evolutionarily conserved control of stress-responsive translation Shyama Nandakumar, Tetyana Lukash, Zeqing Jiang, Charles Joel McManus, Deepika Vasudevan Dept. of Cell Biology, University of Pittsburgh School of Medicine |
| 03:30-03:45pm | Structural basis for repeat-associated non-AUG translation initiation on C9orf72 mRNA Brenna Saladin, Ross Kaufhold, Wenzhao Dong, Ishita Purwar, Suada Leskaj, Clare Wieland, Amy Krans, Erinn Laimon, Indranil Malik, Masaaki Sokabe, Christopher Fraser, Peter Todd, Jailson Brito Querido Department of Biological Chemistry, University of Michigan |
| 03:45-04:00pm | High-throughput discovery of 5UTR structures that regulate translation Alice Youle, Rachel O. Niederer Biological Chemistry, University of Michigan |
| 04:00-04:15pm | Caloric restriction reprograms circadian rhythms in global and selective protein translation. Artem A Astafev, Kuldeep Makwana, Josefa-Marie B. Rom, Nikkhil Velingkaar, Volha Mezhnina, Peng Jiang, Anton A Komar, Roman V Kondratov Cleveland State University |
| 04:15-04:30pm | Spatially localized activation of an RNA helicase facilitates siRNA biogenesis within a phase-separated condensate Brendan Moran, Wen Tang Biological Chemistry and Pharmacology at The Ohio State University |
| 04:30-04:45pm | Structural basis for microRNA-length maintenance Vishal Adhav, Audrey Kehling, Priyanshi Patel, Kotaro Nakanishi Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, 43210, USA. |
| 04:45-05:00pm | Brief break |
Session III: Keynote lecture (chaired by Dr. Deepika Vasudevan) | |
| 05:00-06:00pm | Decoding Translational Reprogramming: Direct and Indirect Molecular Programs Shaping Eukaryotic Gene Expression Dr. Alan Hinnebusch Division of Molecular and Cellular Biology, Eunice K. Shriver National Institute of Child Health and Human Development, National Institutes of Health |
| 06:00-08:00pm | Dinner |
Session IV: Poster session & Reception | |
| 08:00-09:30pm | Odd posters |
| 09:30-11:00pm | Even Posters |
Saturday, Oct 31
| Time | Event |
|---|---|
| 07:00-08:30am | Breakfast |
Session V: Splicing, Transcription & Nuclear RNPs (chaired by Dr. Mohammad Nazim) | |
| 08:30-08:45am | RNA-binding proteins activate transcription through defined molecular grammars Haoran Wang, Lydia Phillips, Dervla Moore-Frederick, Bailey K. Webster, Deyuan Xu, Grant Mowry, Emily Wang, Arth Banka, Sid Srivastava, Biplab K.C, Huaiying Zhang, Changfeng Deng, David M. Chenoweth, Jonathan E. Henninger Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA |
| 08:45-09:00am | Gradual and sudden heat exposure induce distinct alternative splicing programs in green algae Morgan Shine, Karla M. Neugebauer Department of Molecular Biophysics and Biochemistry, Yale University |
| 09:00-09:15am | Synthetic assembly of transcriptional condensates by RNA-binding proteins Bailey Webster, Grant Mowry, Emily Wang, Steven Smeal, Deyuan Xu, Biplab KC, Huaiying Zhang, Changfeng Deng, David Chenoweth, Jonathan Hennigner Department of Biological Sciences, Carnegie Mellon University |
| 09:15-09:30am | A novel SMN mutant implicates correction of UsnRNP biogenesis and pre-mRNA splicing as critically associated with suppression of SMA Anton J Blatnik III, Vicki L McGovern, Summer Baxley, Kaitlyn M Kray, Mitchell Drumm, W David Arnold, Xueyong Wang, Mark Rich, Arthur H M Burghes Genetics & Genome Sciences, Case Western Reserve University School of Medicine |
| 09:30-09:45am | CHD7 regulates replication-dependent histone expression via altered 3 end mRNA processing sa zdemir, Santana Lardo, Sarah Hainer Department of Biological Sciences, University of Pittsburgh |
| 09:45-10:00am | Distinct U1 cofactor requirements link Branaplam and Risdiplam specificity to splice-site context Benjamin Fair, Bo Liu, Zhichao Tang, Junxing Zhao, Yang Li, Jingxin Wang, Zhiling Kuang, Rui Zhao Department of Medicine, University of Chicago |
| 10:00-10:30am | Coffee break |
Session VI: RNA Structure, Tools & Therapeutics (chaired by Dr. Michelle Johnson) | |
| 10:30-10:45am | The iron-sensing czcD riboswitch and its associated protein drive cell viability and infection in Listeria monocytogenes Jacob J. Devos, Girish S. Kirimanjeswara, Joseph A. Cotruvo Jr. Department of Biochemistry and Molecular Biology, Pennsylvania State University |
| 10:45-11:00am | Engineering a Fluorogenic RNA Biosensor toward Selective Imaging of Flavin Adenine Dinucleotide in Living Cells Ziyao Zhu, Kaiyu Fu, Saurja DasGupta Department of Chemistry and Biochemistry, University of Notre Dame |
| 11:00-11:15am | Efficient Zero-footprint Intracellular RNA Labeling via URIL-Stem Replacement and Triplex-guided Covalent Crosslinking Yi-Meng Lo, Dennis Bong Chemistry and Biochemistry, The Ohio State University |
| 11:15-11:30am | Mapping the Structure and Conformational Landscape of the 10-23 DNAzyme Holly Shultz, Evan Cramer, Aaron Robart Biochemistry and Molecular Medicine; West Virginia University |
| 11:30-11:45am | Biophysical evidence for G-quadruplex/hairpin equilibrium in HIV-1 antisense RNA Elise Kelley, Andrew Nielsen , Besik Kankia, Karin Musier-Forsyth Department of Chemistry and Biochemistry, Ohio State University |
| 11:45-12:00pm | Rules of engagement: how small molecules bind RNA in the SPIRAL database Yaqiang Wang Biophysics Department, Medical College of Wisconsin |
| 12:00-12:30pm | Awards and closing remarks |