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Friday, Sep 10

09:00-12:00pmWorkshop 1 Coping Strategies as Professional Development
09:00-12:00pmWorkshop 2 Using CLIP and deep sequencing to map protein-RNA interactions transcriptome-wide
12:30-01:00pmConference site open to login
01:00-01:15pmWelcome and introductory remarks

Session I: Translational Control

01:15-01:30pmRNA binding proteins, upstream open reading frames, and translational control of human gene expression
Cassia Williams-Rogers, Matthew Agar-Johnson, Gemma May, Joel McManus
Department of Biological Sciences, Carnegie Mellon University
01:30-01:45pmDirect analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation by 5′ UTR elements
Rachel O. Niederer, Maria F. Rojas-Duran, Boris Zinshteyn, Wendy V. Gilbert
Molecular Biophysics and Biochemistry, Yale University
01:45-02:00pmEffectors of stress-responsive translational repression in C. neoformans
Corey M. Knowles, John C. Panepinto
Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
02:00-02:15pmPnrc2-dependent mRNA decay and translational control mechanisms promote oscillatory gene expression during vertebrate segmentation
Monica Mannings, Thomas Gallagher, Sharon Amacher
The Ohio State University Molecular Genetics Department
02:15-02:30pmThe Musashi family of stem cell factors is critical for the survival and function of terminally differentiated photoreceptor neurons.
Fatimah Matalkah, Bohye Jeong, Visvanathan Ramamurthy , Peter Stoilov
02:30-03:00pmBYO Coffee Break

Session II: RNA structure and recognition

03:00-03:15pmProbing the structure and function of the Bacillus subtilis thrS T-box riboswitch
Alexander T. Runyon, Tina M. Henkin
Microbiology Department, The Ohio State University
03:15-03:30pmProtein cofactors and substrate dictate Mg2+-dependent structural changes in the catalytic RNA of archaeal RNase P
Ila A. Marathe, Walter J. Zahurancik, Stella M. Lai, Khan L. Cox, Michael G. Poirier, Vicki H. Wysocki, Venkat Gopalan
Department of Chemistry and Biochemistry, Ohio State University
03:30-03:45pmSarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome in a context dependent manner
Zahra Batool, Ivan B. Lomakin, Yury S. Polikanov, Christopher G. Bunick
Department of Biolgical Sciences, University of Illinois at Chicago
03:45-04:00pmCrystal Structure of the RNA Cleaving 10-23 DNAzyme Captured in a Pre-Catalytic State
Evan Cramer, Sarah Starcovic, Aaron Robart
Department of Biochemistry, West Virginia University
04:00-04:15pmPseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures
Meredith K. Purchal, Daniel E. Eyler, Mehmet Tardu, Megan M. Korn, Monika K. Franco, Taslima Khan, Ryan McNassor, Hari Sharma, Leena Malik, Markos Koutmos, Kristin S. Koutmou
Program in Chemical Biology, University of Michigan
04:15-04:30pmHigh-Resolution Profiling of Telomerase RNA Structure Dynamics in the Eukaryotic Pathogen Trypanosoma brucei
Kaitlin E. Klotz, Abhishek Dey, Anais Monroy-Eklund, Justin Davis, Arpita Saha, Bibo Li, Alain Laederach, Kausik Chakrabarti
Department of Biological Sciences-University of North Carolina at Charlotte
04:30-05:00pmCommuter Break
05:00-06:00pmKeynote - Dr Hashim Al-Hashimi, PhD; Duke University School of Medicine
07:30-09:00pmPoster Session I Odd numbers
09:00-10:30pmPoster Session II Even numbers

Saturday, Sep 11


Session III: RNA Triathalon: Synthesis, Processing, and Decay

08:45-09:00amNMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain
Bing Wang, Dmitri Svetlov, Irina Artsimovitch
Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
09:00-09:15amUnderstanding the role of CLP1 in mammalian mRNA transcription and cleavage in neurodegeneration
Geneva LaForce, Jordan Farr, Cydni Akesson, Otis Pinkard, Thomas Sweet, Jeff Coller, Ping Ji, Eric Wagner, Ashleigh Schaffer
Department of Genetics and Genome Sciences, Case Western Reserve University
09:15-09:30ampre-piRNA trimming and 2′-O-methylation protect piRNAs from 3’ tailing and degradation in C. elegans
Benjamin Pastore, Hannah L. Hertz, Ian F. Price, Wen Tang
Department of Biological Chemistry and Pharmacology, Center for RNA Biology, Ohio State Biochemistry Program, The Ohio State University
09:30-09:45am Export, accumulation and degradation of 5’ end-extended, spliced tRNAIleUAU in yeast
William A Marshall, Kunal Chatterjee, Anita K Hopper
Molecular Genetics, Ohio State University
09:45-10:00amUnderstanding the biological significance of multiple zebrafish Trm10 homologs
Ben Jepson, Jane Jackman
Department of Chemistry and Biochemistry, OSU
10:00-10:15amGenetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes
Eddie Park, Yan Jiang, Lili Hao, Jingyi Hui, Yi Xing
Center for Computational and Genomic Medicine, The Childrens Hospital of Philadelphia
10:15-10:30amGlobal RNA binding analysis defines the hierarchy of RNA-UPF protein interactions during early stages of NMD
Savannah Mills, DaJuan Whiteside, Kristian E Baker
Department of Biochemistry, Case Western Reserve University
10:30-11:00amBYO Coffee Break

Session IV: RNA in Health and Disease

11:00-11:15amMetabolic starvation in tumors regulates Alternative Splicing to potentiate tumorigenicity
Safiya Khurshid, Ruoning Wang , Dawn Chandler
Abigail Wexner Research Center, Nationwide Childrens Hospital
11:15-11:30amVaccinia virus K7 protein inhibits biochemical activities and liquid-liquid phase separation of the DEAD-box RNA helicase DDX3X
Sarah Venus, Kaba Tandjigora, Eckhard Jankowsky
Center for RNA Science and Therapeutics, Case Western Reserve University
11:30-11:45amTitle not published online - please see booklet
Ullas V. Chembazhi, Chaitali Misra, Sushant Bangru, Auinash Kalsotra
Department of Biochemistry, University of Illinois, Urbana-Champaign, Illinois, USA
11:45-12:00pmTitle not published online - please see booklet
Mariah K. Novak, Qiuying Liu, Rachel Pepin, Wenqian Hu
Biochemistry and Molecular Biology, Mayo Clinic
12:00-12:15pmmicroRNA-mediated regulation of microRNA machinery controls cell fate decisions
Rachel M. Pepin, Qiuying Liu, Mariah K. Novak, Taylor Eich, Wenqian Hu
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA
12:15-12:35pmStructural investigation of the oncomiR-1 RNA
Sarah C. Keane
Departments of Biophysics and Chemistry, University of Michigan
12:35-12:55pmFMRP inhibits translation elongation independent of RNA G-quadruplexes
MaKenzie R. Scarpitti , Michael G. Kearse
Department of Biological Chemistry and Pharmacology, Center for RNA Biology, The Ohio State University, Columbus, OH 43210 USA
01:00-01:30pmAwards ceremony and closing comments