Friday, Oct 23

09:30-12:00pmBioinformatics Workshop
12:00-12:30pmConference site open to login
12:30-01:00pmWelcome and introductory remarks

Session I: Plenary 1. Phase Separation and RNA Binding Proteins

01:00-01:15pmHuman Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA
GeunYoung Sim, Mi Seul Park, Audrey C. Kehling, Kotaro Nakanishi
Molecular, Cellular and Developmental Biology and Center for RNA Biology, The Ohio State University
01:15-01:30pmProtein Arginine Methylation Regulates Long Non-coding RNAs in Cryptococcus neoformans
Murat C. Kalem, Harini Subbiah, John C. Panepinto
Department of Microbiology and Immunology - SUNY University at Buffalo
01:30-01:45pmThe role of Musashi proteins in the maintenance of mature photoreceptor cells
Fatimah Matalkah, Bohye Jeong, Visvanathan Ramamurthy , Peter Stoilov
01:45-02:00pmNucleotide-level resolution of RNA folding interactions within peptide-based complex coacervates
McCauley Meyer, Saehyun Choi, Fatma Pir Cakmak, Philip C. Bevilacqua, Christine D. Keating
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802
02:00-02:15pmNot just a phase: understanding ribosome biogenesis using liquid-liquid phase biology
Amber J. LaPeruta, Jelena Micic, Daniel M. Wilson, Fiona Fitzgerald , John L. Woolford Jr.
Carnegie Mellon University Department of Biological Sciences
02:15-02:30pmUtilization of high-pressure NMR for the study of an intrinsically disordered domain of hnRNP A1
Jeffrey D. Levengood, Jake Peterson, Julien Roche, Blanton S. Tolbert
Department of Chemistry, Case Western Reserve University
02:30-03:00pmBYO Coffee Break - Conference site main hall

Session II: Plenary 2. Translational Control

03:00-03:15pmuORF control of cardiac gene expression: Lessons learned from a single nucleotide that regulates cardiomyocyte biology
Omar M. Hedaya, Feng Jiang, Venkata Kadiam, Jiangbin Wu, Darren Khorr, Peng Yao
Biochemistry and Biophysics, University of Rochester
03:15-03:30pmPumilio-mediated post-transcriptional regulation of DICER1 protein in Dicer1 syndrome
Swetha Rajasekaran, Wayne Miles
Department of Molecular Genetics, The Ohio State University
03:30-03:45pmDynamic Phosphorylation Regulates Eukaryotic Translation Initiation Factor 4A Activity During The Cell Cycle
Ansuman Sahoo, Marium Ashraf, Sarah E. Walker
Department of Biological Sciences, University at Buffalo
03:45-04:00pmPnrc2-dependent mRNA decay and translational control mechanisms promote oscillatory gene expression during vertebrate segmentation
Monica Mannings, Thomas Gallagher, Kiel Tietz, Sharon Amacher
The Ohio State University Molecular Genetics Department
04:00-04:15pmHuman UPF3-dependent nonsense-mediated mRNA decay is regulated by a specific exon junction complex composition
Zhongxia Yi, Guramrit Singh
Department of Molecular Genetics, Center for RNA Biology, The Ohio State University
04:15-04:30pmUnraveling the roles of 5’ transcript leaders in gene regulation
Christina Akirtava, Hunter Kready, Lauren Nazzaro, Matt Agar-Johnson, Gemma E May, C. Joel McManus
Carnegie Mellon University, Biological Sciences
04:30-06:00pmDinner / Commuter Break
06:00-07:00pmKeynote - Dr Rachel Green, PhD; HHMI and Johns Hopkins University
07:30-09:00pmPoster Session I Odd numbers
09:00-10:30pmPoster Session II - Even Numbers

Saturday, Oct 24


Session III: RNA biology of SARS-CoV-2 session

09:30-09:55amTargeting −1 programmed ribosomal frameshiting of SARS-CoV-2
Yu Sun, Laura Abriola, Yulia Surovtseva, Brett Lindenbach, Junjie Guo
Department of Neuroscience, Yale University
10:00-10:30amRNA Therapeutics: Informational drugs as a pandemic response tool
Anastasia Khvorova
University of Massachusetts Medical School
10:30-11:00amAccelerated 3D RNA structure determination and the SARS-CoV-2 genome
Zhang, K., Zheludev, I. N., Hagey, R. J., Wu, M. T.-P., Haslecker, R., Hou, Y. J., Kretsch, R., Pintilie, G. D., Rangan, R., Kladwang, W., Li, S., Pham, E. A., Bernardin-Souibgui, C., Baric, R. S., Sheahan, T. P., D Souza, V., Glenn, J. S., Chiu, W., Das, R.
Biochemistry Department, Stanford University
11:00-12:30pmWorkshop on promoting Diversity, Equity, and Inclusion in biomedical research
12:30-01:00pmLunch Break

Session IV: Plenary 3. tRNAs and RNA modifications

01:00-01:15pmStructure and assembly of human Multi-tRNA Synthetase Complex reveals novel mechanism of disease association
Krishnendu Khan, Camelia B. Gogonea, Belinda Willard, Valentin Gogonea, Paul L. Fox
Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, USA
01:15-01:30pmA missense variant impairing TRMT1 function in tRNA modification is linked to intellectual disability
Kejia Zhang, Dragony Fu
Department of Biology, Center for RNA Biology, University of Rochester
01:30-01:45pmADAR3 alters the MAVS/NF-κB signaling pathway in glioblastoma
Reshma Raghava Kurup, Emilie Oakes, Aidan Manning, Pranathi Vadlamani, Heather A. Hundley
Genome, Cell and Developmental Biology Program, Indiana University
01:45-02:00pmDevelopmental regulation of edited CYb and COIII mitochondrial mRNAs is achieved by distinct mechanisms in Trypanosoma brucei
Joseph T. Smith Jr., Eva Dolezelova, Alena Zikova, Brianna Tylec, Jonathan Bard, Runpu Chen, Yijun Sun, Laurie K. Read
Department of Microbiology and Immunology, University at Buffalo
02:00-02:15pmRole of unique C-terminal domain in a plant aminoacyl-tRNA trans-editing protein
Jun-Kyu Byun, John Vu, William A. Cantara, Jawad Abid, Jyan-Chyun Jang, Karin Musier-Forsyth
Department of Chemistry and Biochemistry, The Ohio State University
02:15-02:30pmDisease-associated point mutations in a bifunctional aminoacyl-tRNA synthetase elicit the integrated stress response
Danni Jin, Nathan Kudlapur, Ronald Wek, Karin Musier-Forsyth
Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus OH 43210
02:30-02:45pmBYO Coffee Break - Conference site main hall

Session V: Plenary 4. Functional RNA structures

02:45-03:00pmChemistry and catalysis join forces in prebiotic RNA ligation
Saurja DasGupta, Travis Walton, Daniel Duzdevich, Seung Soo Oh, Jack Szostak
Molecular Biology, Massachusetts General Hospital
03:00-03:15pmStructural basis of sequestration of the Anti-Shine-Dalgarno sequence in the Bacteroidetes ribosome
Zakkary A. McNutt, Bappaditya Roy, Bethany L. Boleratz, Dean E. Watkins, Vikash Jha, Dushyant Jahagirdar, Kaustuv Basu, Elan A. Shatoff, Ralf Bundschuh, Joaquin Ortega, Kurt Fredrick
Department of Microbiology & Center for RNA Biology & The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
03:15-03:30pmStructure-function relationship in biogenesis of microRNA-31
Anita Kotar, Sarah Keane
Biophysics program, University of Michigan
03:30-03:45pmSequence and structure control assembly of RNA condensates
Raghav Poudyal, Jacob Sieg, Bede Portz, Christine Keating, Philip Bevilacqua
Chemistry, Pennsylvania State University
03:45-04:05pmTranslational induction of ATF4 mRNA during stress requires noncanonical initiation factors eIF2D and DENR
Deepika Vasudevan, Sarah D. Neuman, Amy Yang, Arash Bashirullah, Hyung Don Ryoo
Cell Biology, NYU School of Medicine
04:05-04:25pmlncRNA phase separation in nuclear organization.
Huaiying Zhang
Carnegie Mellon University
04:30-05:00pmAwards ceremony and closing comments