Talk abstracts
Talk on Friday 05:00-06:00pm submitted by Karla Neugebauer
Co-transcriptional RNA processing enables RNA to be a first responder
Karla Neugebauer (Molecular Biophysics and Biochemistry, Yale University)
Abstract:
Many steps in RNA biogenesis occur during synthesis by RNA polymerases. Co-transcriptional activities are deemed commonplace in prokaryotes, where the lack of membrane barriers allows mixing of all gene expression steps. In the past decade, an extraordinary level of coordination between transcription and RNA processing has emerged in eukaryotes. Hi will discuss recent developments in our understanding of co-transcriptional processing and talk about our unpublished studies on the coordination between RNA folding, splicing, polyadenylation as transcription proceeds. I will highlight how co-transcriptional coordination drives fundamental aspects of gene expression, including gene output, and argue that co-transcriptionality enables rapid responses to cellular changes in many contexts.
Keywords: pre-mRNA processing, transcription, nascent RNA