Poster abstracts
Poster number 29 submitted by Kayla Lenshoek
MALAT1 promotes cancer cell plasticity through reversible control of EMT
Kayla Lenshoek (Cellular and Molecular Biology University of Michigan Medical School, Ann Arbor, MI ), Brittany Bowman Ph.D (Department of Biological Chemistry University of Michigan Medical School, Ann Arbor MI), Chase Weidmann Ph.D (Department of Biological Chemistry University of Michigan Medical School, Ann Arbor MI, Center for RNA Biomedicine University of Michigan, Ann Arbor MI, Rogel Cancer Center University of Michiga)
Abstract:
Noncoding RNAs often exhibit context-dependent activities. High levels of Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) correlate with metastasis in numerous cancers, including lung cancer, and its depletion inhibits this effect in multiple models. Curiously, normal cells often express higher MALAT1 levels than cancer cells, yet MALAT1 loss in healthy cells and wild-type mice causes no viability defect. The mechanisms underlying this cancer-specific
Keywords: MALAT1, ncRNA, metastasis