Poster abstracts
Poster number 54 submitted by Jae-Hee Bae
Exons are spliced in coordination with their neighbors as a consequence of splicing order and exon junction complex dependence
Jae-Hee Bae (Molecular Biophysics and Biochemistry, Yale University), Alexandra Bergfort (Molecular Biophysics and Biochemistry, Yale University), Shriya Krishna (Molecular Biophysics and Biochemistry, Yale University), Karla M. Neugebauer (Molecular Biophysics and Biochemistry, Yale University)
Abstract:
All human genes with multiple exons undergo splicing, during which the exon junction complex (EJC) is typically deposited 20-24 nucleotides upstream of the spliced junction. The EJC is subsequently involved in mRNA export and stability. We recently discovered that the depletion of the EJC’s RNA-binding component EIF4A3 causes coordinated skipping of neighboring exon pairs on the same transcript, defining a previously unrecognized splicing unit we term
Keywords: Exon junction complex, Exon blocks, RNA splicing