Poster Abstracts

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Number	Presenter	Title	PI
112	Zachary Parada	Impact of Molecular Crowding Agents on RNA Aptamer Biosensors	Aaron E. Engelhart
35	Mariana Correia	The role of hAGO1 variants in neurodevelopmental disorders	Anita Hopper
131	Paolo Sinopoli	Free tRNA introns act as novel noncoding regulatory RNAs	Anita Hopper
162	Ernesto Roldan-Bonet	Genome-wide application of a tRNA assay to uncover proteins involved in the tRNA nuclear retrograde pathway	Anita Hopper
33	Sophie Cihan	Binding Preferences amongst Three Saccharomyces cerevisiae tRNA Primary Nuclear Exportins	Anita Hopper
148	Annie Witzky	Elongation Factor P is required for antibiotic resistance in β-lactam resistant Escherichia coli	Annie Witzky
160	Lichun Zhou	The polyadenylation factor CPSF30 is important for root development and plant response to salt stress	Arthur Hunt
90	Shaokun Li	Dissecting the role of CLP1 in RNA maturation and alternative polyadenylation through the R140H mutation	Ashleigh Schaffer
28	Anthony Caputo	Investigating the mechanisms of cell-type-specific alternative polyadenylation	Ashleigh Schaffer
39	Diptatanu Das	Dysregulated RNA splicing network drives regeneration failure causing hepatic decompensation in alcohol-associated liver disease	Auinash Kalsotra
43	Jessica Derham	Dynamic Expression of Epithelial Splicing Regulatory Protein 2 Promotes Cell Migration and Proliferation to Enable Regeneration Following Drug-Induced, Acute Liver Injury	Auinash Kalsotra
12	Nicholas Baker	Temporally controlled expression of a splicing factor in single cells coordinates the metabolic and proliferative activities of regenerating livers	Auinash Kalsotra
32	Sandip Chorghade	Dynamic expression of the nuclear poly(A) binding protein N1 is critical for postnatal Heart development and disease.	Auinash Kalsotra
2	Oluwafolajimi Adesanya	Myotonic Dystrophy type I (DM1) Impairs Cardiac Bioenergetics and Disrupts Cardiac Mitochondrial Fusion-Fission Dynamics	Auinash Kalsotra
119	Johann Roque	Covalent Ligand Discovery for Selectively Targeting Homologous RNA Binding Protiens: hnRNP H and F	Brittany Morgan
147	Adam Wier	The AUGCs: Learning the chemistry of RNA through a mass-spectrometry screen of electrophiles	Brittany Morgan
157	Lizette Zavala	Expanding the function and activity of a unique deadenylase involved in non-coding RNA processing and regulation	Cassandra Hayne
132	Emily Slobodenyuk	Identifying the role of 3’UTRs in transcriptional regulation of the calmodulin gene family	Chase Weidmann
24	Jae Bucknor	Understanding how ncRNA Impact the NRF2 Antioxidant Response in Lung Cancer	Chase Weidmann
88	Kayla Lenshoek	Uncovering how lncRNA MALAT1 controls gene expression in cancer metastasis	Chase Weidmann
68	Sun Jeong Im	Calculations of pKa values for canonical nucleosides and nucleoside analogs	Christine Chow
150	Andrew Yaldo	Experimental determination of pKa values of canonical and analogue nucleosides	Christine Chow
134	Ankita Srivastava	SARS-CoV-2 Infection Alters CPSF73 Expression, Modulating Immune Response via Alternative Polyadenylation	Claire Moore
23	Christopher Bonar	Synonymous codon substitutions enhance transcription and translation of an upstream gene in E. coli	Clark Patricia
17	Chayan Bhattacharya	Epigenetic And LncRNA Regulation In Vascular Cells Under Cancer Therapy-Induced Stress	Cristina Espinosa-Diez
122	Sydney Rudolph	Role of the lncRNA MEG9 in Vascular Endothelial Cells in Response to Stress	Cristina Espinosa-Diez
117	Rafia Rahat	AAV-delivered Splice Switching Oligonucleotides: Restoring p53 function through MDM2 splicing modulation	Dawn Chandler
72	Whitney Jimenez	Distal elements in the MDM2 gene facilitate an eight-exon splicing event by coordinating multiple splice regulatory proteins	Dawn Chandler
86	Zac LaRocca-Stravalle	Unveiling the Alternative Splicing Landscape in Hepatoblastoma: Enhancing Prognostic and Therapeutic Approaches	Dawn Chandler
108	Shyama Nandakumar	Micropeptide-mediated regulation of mRNA translation during ER stress	Deepika Vasudevan
141	Rheanna Walther	Mutation of C. albicans snR10c leads to translational inhibitor sensitivity	Doug Bernstein
67	Michael Hrabak	Pseudouridine synthase 1 becomes localized more to the cytoplasm during stress in C. albicans	Doug Bernstein
53	Samantha Gargasz	Post-Transcriptional Regulation of AR Variant 7 in Castration-Resistant Prostate Cancer	Girish Shukla
123	Manu Sanjeev	PYM1 limits non-canonical binding of exon junction complex and maintains homeostatic expression of mRNAs localized to endoplasmic reticulum	Guramrit Singh
8	Rene Arvola	Investigating the interactome and functions of the UPF3 paralogs in Nonsense Mediated mRNA Decay	Guramrit Singh
127	Savanna Schutte	Exploring the roles of UPF3 functional domains within Nonsense-Mediated mRNA Decay	Guramrit Singh
48	Caleb Embree	Pleiotropic Effects of Spliceosome Disruption Include Upregulation of Nonsense-Mediated mRNA Decay Targets	Guramrit Singh
31	Wannasiri Chiraphapphaiboon	XPO1 and topoisomerase-1 inhibitors synergistically sensitize XPO1-mutant colorectal cancers	Hai Dang Nguyen
133	Niraja Soman	RNase H1-S233A mutant fails to suppress R loop associated genomic instability	Hai Dang Nguyen
82	Sineth G Kodikara	Protection of the Telomeric Junction by the Shelterin Complex	Hamza Balci
3	Janan Alfehaid	Reusable Microfluidic Chambers for Single-Molecule Microscopy	Hamza Balci
13	Hamza Balci	Protection of Long Telomeric Overhangs by Shelterin	Hamza Balci
151	Boyoon Yang	Gathering insights into differences between substrate recognition by ADR-1 and ADR-2 in vivo	Heather Hundley
96	Ananya Mahapatra	The kinase GSK-3 is a novel regulator of ADR-1 RNA recognition in the C. elegans nervous system	Heather Hundley
85	Emma Lamb	Defining a co-regulatory relationship between RNA binding proteins ADR-2 and TDP-1 in C. elegans nervous systems	Heather Hundley
45	Alfa Dhakal	Combines loss of ADARs and RDE-4 provides resistance to an opportunistic human pathogen	Heather Hundley
49	Emily Erdmann	ADR-2 regulates the germline transcriptome and affects fertility and oocyte fate	Heather Hundley
38	Ruwani Madushika Dalath	Imaging lncRNA TERRA using γPNA probes	Huaiying Zhang
159	Xinyu Zhao	Abrogation of intronic polyadenylation: CRISPR/Cas9-based gene-editing to circumvent acquired resistance to DNA Topoisomerase II-targeted anticancer agents	Jack Yalowich
5	Thaanya Amarasekara	Substrate specificity and 3'-5'-polymerization capabilities of two tRNA His guanylyltransferase-like proteins	Jane Jackman
70	Brandon Iwaniec	Investigating functions outside of tRNA for a bacterial 3'-5' reverse polymerase from the Thg1/TLP superfamily	Jane Jackman
120	Olivia Roumaya	Investigation of a unique vertebrate tRNA modification by Trmt10b in zebrafish	Jane Jackman
97	Nisha Makkar	Identification of unique tRNA-specific effects of tRNA modifying enzymes on 5-fluorouracil toxicity in Saccharomyces cerevisiae	Jane Jackman
54	Aishwarya Ghosh	Bacterial translation initiation factor IF-2’s N-terminal IDR promotes cold-induced phase separation	Jared Schrader
84	Hiranthi Kulathungage	Rif-seq reveals C. crescentus mRNA decay is globally coordinated with transcription and translation	Jared Schrader
98	Kaveendya Mallikaarachchi	Bacterial mRNA Decay Condensates are Broadly Conserved Across Bacterial Species and Play a Critical Role in Host Colonization	Jared Schrader
153	Hadi Yassine	BR-bodies switch from mRNA decay to mRNA storage in stationary phase	Jared Schrader
87	Vincent Lawal	Caulobacter RppH and NudC have Direct and Indirect Effects on mRNAs	Jared Schrader
99	Oliver Marchus	x1 encodes a putative RNA-binding protein required for paramutation	Jay B. Hollick
136	Alejandro Tapia	Engineered Suppressor tRNAs Rescues Nonsense Mutations In TP53	Jeffery Tharp
41	Olabode Dawodu	Engineering Aminoacyl-tRNA Synthetases (aaRS)/tRNA Pairs to Recognize Cysteine-Reactive Unnatural Amino Acids to Generate Bacterial-Displayed Cyclic Peptides	Jeffery Tharp
74	Daniel Judge	Studying the Mechanism for Ribosome-Inactivating Protein-Induced Apoptosis	Jen Gallagher
52	Jen Gallagher	When does splicing do more than remove introns?	Jen Gallagher
102	Taizina Momtareen	Investigating the transcriptomic changes in response to telomerase loss in Saccharomyces cerevisiae	Jen Gallagher
62	Danushika Herath	CHARACTERIZATION of Transcription Product Outcomes in T-box Riboswitch Modulation	Jennifer Hines
6	Deborah Amesaki	RNA-Targeted Drug Design: Impact of pH on Fragment-Based Ligand Discovery	Jennifer Hines
51	Opeyemi Fatunbi	NUCLEOBASE protonation in an RNA Thermometer	Jennifer Hines
140	Nikhil Vijai	Elucidating the structure of the 3′ end of premature MALAT1 using SHAPE	Jessica Brown
55	Madeline Glennon	Structural elucidation of an RNA triple helix in complex with a small molecule	Jessica Brown
125	Mika Schievelbein	The 3' end of MALAT1 forms a partial triple helix in the presence of mascRNA	Jessica Brown
21	Koppany Bodor	Magnesium Ions Increase, but Potassium Ions Decrease, the Thermal Stability of the MALAT1 RNA Triple Helix	Jessica Brown
106	Rohan Munoth	Ribosome pausing analysis in Cryptococcus neoformans	Joel McManus
42	Kara Delbridge	Multi-Color Single-Molecule Tracking of Stop-Codon Readthrough on the Vitamin D Receptor mRNA in Live Cells	Joel McManus
71	Zeqing Jiang	The Role of 5’ UTR in gene expression regulation	Joel McManus
73	Lucia Johnson	Translational control of a unique bicistronic gene linked to Prader-Willi Syndrome	Joel McManus
60	Stefanie Hedayati	The role of IDRs in the assembly pathway of pre-ribosomes	John Woolford
130	Shashi Singh	Dual-Action Circular ADAR-Recruiting RNAs: A Novel Approach for Reversible Gene Modulation through RNA Editing and Antisense Effects	Joseph Luna
83	Vidusha Kothwela	Orthogonal Organic Phase Separation (OOPS) Reveals Cellular RNA Binding Proteome Changes in Response to Flavivirus Infections	Joseph Luna
69	Amra Ismail	ADAR1 Suppresses PKR-Mediated Stress Granule Oscillations in Interferon-Stimulated Cells	Joseph Luna
64	Laura Hertz	High-throughput molecular evolution function exploration of the fluoride riboswitch	Julius Lucks
103	Michael Muccio	Transcriptional start site usage in the HIV-1 genome dictates dimerization and selective packaging by modulating polyA stem stability	Karin Musier-Forsyth
14	Morgan Bauer	Enzymatic Characterization of Full-length Glutamyl-Prolyl-tRNA Synthetase (EPRS) and Disease-associated Mutants	Karin Musier-Forsyth
76	Joe Kanlong	Translational control of HIV-1 unspliced RNA is regulated at the level of transcription through an RNA structure-guided mechanism	Karin Musier-Forsyth
81	Kaitlin Klotz	Investigation of telomerase reverse transcriptase (TERT) ubiquitination and telomerase regulation in the parasitic protozoan, Trypanosoma brucei	Kausik Chakrabarti
27	Carli Camporeale	Nucleotide-resolution Mapping of RNA N6-Methyladenosine (m6A) in Malaria Pathogen Plasmodium falciparum and Determining m6A’s Role in Host–Pathogen Interactions	Kausik Chakrabarti
161	Sihang Zhou	Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations	Kevin Van Bortle
158	Huaqun Zhang	Gene silencing by cityRNAs	Kotaro Nakanishi
114	Chathuri Pathirage	Codon and tRNA coevolution in Lactobaccilales impact on translation speed and accuracy	Kristin Koutmou
156	Maddy Zamecnik	Incorporating common ASO modifications into mRNAs impacts translation speed	Kristin Koutmou
129	Kaley Simcox	Quantitative mapping of modified RNA nucleosides in tRNAs	Kristin Koutmou
121	Minli Ruan	PUS7 cytoplasmic localization directs a pseudouridine-mediated cellular stress response	Kristin Koutmou
91	Xiaoyan Li	Identifying the mechanism of PUS7 relocalization upon stress	Kristin Koutmou
105	Hailey Mulvihill	Examining tRNA Quality Control in Yeast Cells Under Oxidative Stress Conditions	Kunal Chatterjee
145	Benjamin Warner	Contribution of an alternative 16S rRNA helix to biogenesis of the 30S subunit of the ribosome	Kurt Fredrick
138	Annie Urban	Investigating the role of bS21 paralogs in ribosome heterogeneity in Agrobacterium fabrum	Kurt Fredrick
50	Sepideh Fakhretaha Aval	Role of the sarcin-ricin loop of 23S rRNA in biogenesis of the 50S ribosomal subunit	Kurt Fredrick
107	Fawwaz Naeem	Why Bacteroidia ribosomes tuck in their tails	Kurt Fredrick
4	Siddik Alom	Protein bL38 facilitates incorporation of uL6 during assembly of the 50S subunit in Flavobacterium johnsoniae	Kurt Fredrick
10	Aouss Azzouz	Generating ProXp-x Active Site Mutations to Determine the Mechanism of D-aa-tRNA Selection	Lexie Kuzmishin Nagy
110	Dilshodbek Nishonov	Live-Cell Chromatin Looping by CRISPR and Engineered gRNAs	Li-Chun Tu
36	Allan Victor Cortes	Exon 10 skipping of ATXN3 as a potential therapy for Spinocerebellar Ataxia type 3 (SCA3)	Mallory Havens
34	Amelia Cochran	Investigation of Pus4 Substrate Selection	Markos Koutmos
77	Abigail Kelly	Investigating tRNA maturation by Protein-Only RNase P (PRORP) & the Elucidating the Role of Interacting Methyltransferases in Arabidopsis thaliana	Markos Koutmos
149	Matthew Yacoub	Characterizing Structural and Thermodynamic Properties of a Human Homolog of TRMT1	Markos Koutmos
79	Ingrid Kilde	Discovery of novel FMN Riboswitch Binding Partners using an Interdisciplinary Approach	Markos Koutmos
11	Rebecca Bailey	Meiotic viability of telomere-free circular chromosomes in the eukaryote Saccharomyces cerevisiae	Melissa Mefford
44	Alisha Detmer	Investigating the Interaction Between Yeast tRNA Modification Proteins Trm7 and Trm734	Michael Guy
92	Anabel Lillie	Determining the role of Trm7, Trm732, and Trm734 in tRNA binding	Michael Guy
25	Anh Bui	Determination of the effect on translation of 2’-O-methylation at positions 32 and 34 in eukaryotic tRNA	Michael Guy
37	Natalie Creech	Determining the role of the tRNA methyltransferase Trm7:Trm734 in repression of TY1 elements in yeast	Michael Guy
46	Trevor Doiron	Dissecting the role of protein arginine methylation on the function of Snp1, the yeast homolog of human U1-70K	Michael Yu
109	Paige Nati	Investigating the dynamic regulation of arginine methylation on the SR-/hnRNP-like protein Npl3	Michael Yu
57	Aastha Gyawali	Simplifying eukaryotic transfer RNA Modification Mapping via FPLC	Pat Limbach
118	Asif Rayhan	Nucleoside modification mapping by genome-independent universal mass exclusion list of unmodified oligonucleotides during LC-MS/MS	Pat Limbach
59	Mohammed Hassan	Quantification of RNA nanoparticles in the eye tissues using LC-MS	Pat Limbach
155	Hina Zain	Liquid Chromatography-Mass Spectrometry Analysis of Total tRNA using RNase 4	Pat Limbach
80	Jennifer Kist	Offline HPLC fractionation and LC-MS/MS characterization of tRNAs	Pat Limbach
19	Daniel Binzel	Sterical configuration beyond conformation to RNA-protein interaction for executing functions in biological systems	Peixuan Guo
18	Archie Bhullar	Engineered Extracellular Vesicles for Combinatorial TNBC Therapy: SR-SIM-Guided Design Achieves Substantial Drug Dosage Reduction	Peixuan Guo
22	Margaret Bohmer	Interaction of a hexameric RNA with a dodecameric protein complex to produce a stable structure without induced-fit but with conformational capture	Peixuan Guo
124	Md Sharear Saon	Identifying and characterizing charged and tautomeric G•U wobbles in RNA	Phil Bevilacqua
93	Huazhen Liu	Involvement of the plant polyadenylation factors FIP1 and CPSF30 in immune responses	Pradeep Kachroo
29	Defne Ceyhan	Predicting the subcellular localization of RNA-binding proteins	Quaid Morris
56	Maddie Goodman	Characterization and quantification of nucleic acid methylation catalyzed by the MTR1 ribozyme	Rachel Mitton-Fry
100	Cesar Martinez	Mapping translation initiation sites using the bacterial toxin RelE	Rachel Niederer
154	Alice Youle	Translational output of CFTR is regulated by multiple elements in 5’UTR	Rachel Niederer
16	Dana Beseiso	Investigating functional transcription start site switching in breast cancer	Rachel Niederer
65	Audrey Hoelscher	The Role of YHR020W 5’ UTR Isoforms in Stress Tolerance	Rachel Niederer
116	Ben Pockrass	Translation at the ER: Developing a smART-ER method	Rachel Niederer
66	Jacob Horn	Comprehensive analysis of SARS-CoV-2 5’ UTR functional elements that facilitate evasion of Nsp1-mediated translational shutdown	Rachel Niederer
139	Leidy Johana Vanegas Cano	Investigating the role of ribosomal RNA pseudouridylation in regulating translation	Rachel Niederer
126	Michael Schiff	Understanding Connections between PYM1 Function in Exon Junction Complex Binding and Gene Architecture	Ralf Bundschuh
142	Danielle Wampler	Computational modelling of RNA-protein binding interactions under an external force	Ralf Bundschuh
101	Aftab Mollah	Unveiling the sequence-specific recognition of N6-methyladenosine (m6A) in eukaryotic RNAs	Sanjaya Abeysirigunawardena
137	Chamali Thalagaha Mudiyanselage	Fused in Sarcoma protein recognizes and binds to mRNA methylation	Sanjaya Abeysirigunawardena
47	Chathurani Ekanayake	Investigation of the ability of 5-methylcytosine to modulate RNA-protein interactions in humans	Sanjaya Abeysirigunawardena
94	Yaping Liu	Structural elucidation of the 3’ oncomiR-1 RNA by NMR spectroscopy	Sarah Keane
146	Megan Westwood	Investigating structural features of pre-miR-122 that affect Dicer processing	Sarah Keane
111	Martin OSteen	A Regulatory RNA:RNA interaction in Listeria monocytogenes	Sarah Keane
58	Cade Harkner	Identification and characterization of proteins that interact with the oncomiR-1 NPSL2 hairpin which may regulate miR-92a biogenesis through directing RNA conformational change	Sarah Keane
135	Sydney Steele	Probing functional differences in pri-miR-20a binding by the 2 RRMs of hnRNPA2B1	Sarah Keane
7	Grace Arhin	Identification and Characterization of Small Molecules Targeting Oncogenic Pre-miR-31	Sarah Keane
78	Seth Kelly	The evolutionarily conserved polyadenosine RNA binding protein Nab2 regulates mRNA splicing in the developing Drosophila melanogaster nervous system	Seth Kelly
9	Clare Austin	Identification of segmentation clock oscillatory transcripts in the zebrafish presomitic mesoderm	Sharon Amacher
75	Mohammad Lutful Kabir	Combined CRISPR-activation and CRISPR-interference capabilities using dCas9 and G-quadruplex Structures	Soumitra Basu
61	Noah Helton	Ribosome association excludes stress-induced gene mRNAs from stress granules	Stephanie Moon
15	Max Baymiller	tRNA synthetase activity is required for stress-induced RNP granule assembly	Stephanie Moon
26	Erika Calle Urgiles	Live Cell Imaging of Cell Cycle Stages And Its Effect on Stress Response	Stephanie Moon
20	Christopher Blum	Engineering Exosomes Through Versatile Oligonucleotide Tethers	Subha Das
89	Lauren Levesque	Identification of mediators of NOTCH-dependent mRNA degradation during vertebrate segmentation	Susan Cole
152	Xiaoyuan Yang	Oligomerization-mediated activation of a short prokaryotic Argonaute	Tianmin Fu
30	Jenny Ruiying Cheng	The NuRD chromatin remodeler as a novel regulator of RNA polymerase III and the small RNA universe	Van Bortle Kevin
95	Simon Lizarazo	A Multi-tissue and cancer atlas of Pol III activity uncovers context-specific transcriptional expansion to genes implicated in disease progression	Van Bortle Kevin
128	Vaishnavi Sidharthan	Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P	Venkat Gopalan
40	Moulisubhro Datta	Exploring the role of a tRNA SNP in the molecular basis of dextrocardia, a laterality disorder	Venkat Gopalan
104	Swapnil Mukherjee	Dissecting the Mechanism of IRE1 Activation with Orthogonal Control over Oligomerization and Phosphorylation	Vladislav Belyy
63	Hannah Hertz	Investigating the role of kinetochore component HCP-1 perinuclear condensates for successful cell division in C. elegans	Wen Tang
113	Benjamin Pastore	Determination of the mechanisms governing piRNA degradation	Wen Tang
144	Yi-Hui Wang	An AT-hook transcription factor promotes transcription of histone, spliced-leader, and piRNA clusters	Wen Tang
115	Brendan Pew	Title not published online	Wen Tang
143	Chin Wang	Investigating AT-hook Proteins and Their Role in PATC-Mediated Gene Regulation in C. elegans	Wen Tang
1	Thilini Abeywansha	Structural basis of tRNA recognition by arginyl-tRNA-protein transferase 1	Yi Zhang