Poster Abstracts

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Number	Presenter	Title	PI
52	Joseph Heili	Activation of caged functional RNAs by oxidative desulfurization of 2-thiouridine	Aaron Engelhart
54	Tanner Hoog	Nucleolin Potentially Regulates G4-Duplex Equilibration During Ribosome Maturation Through Chaotropic Residues	Aaron Engelhart
8	Lauren Aufdembrink	RAQ-NASBA: Rapid, Aptamer-detected, Quantitative Nucleic Acid Sequence Based Amplification	Aaron Engelhart
109	Matthew Pawlak	Perchlorate brine abrogates protein function whereas ribozymes thrive	Aaron Engelhart
79	Yichen Liu	Title not published online	Aaron Frank
161	Ziqiao Xu	De Novo Nucleic Acid Design Using Variational Autoencoder	Aaron Frank
85	Claire Mazahery	Opioid-induced long noncoding transcriptome of human CD8+ T cells reveals opioid receptor subclass specific responses	Alan Levine
120	Hafiz Rothi	Noncoding RNA-mediated DNA methylation controls nucleosome positioning	Andrzej Wierzbick
105	V. Miguel Palomar	Structural features of plastid chromatin	Andrzej Wierzbicki
103	Vishal Nanavaty	DNA methylation regulates alternative polyadenylation via CTCF and the cohesin complex	Angela Ting
104	Gina Nostramo	Do tRNA introns have a biological function?	Anita Hopper
149	Megan Van Horn	Towards understanding the role of circRNAs in intracellular signaling pathways	Anna M. Kietrys
16	Anton Blatnik	Identification of Functional SMNs and Suppressors of the Nonfunctional SMNE134K	Arthur H M Burghes
74	Kuan-Chieh Leu	CstF complex regulates an unique polyadenylation machinery in Arabidopsis thaliana	Arthur Hunt
38	Jordan Farr	Pathogenic CLP1 p.R140H mutation alters mRNA processing in human motor neurons	Ashleigh Schaffer
44	Zac Dewald	The role of Myotonic Dystrophy Type 1 in the Liver	Auinash Kalsotra
173	Bo Zhang	Identification of the mechanism for PABPN1 translational repression during cardiac development and hypertrophy	Auinash Kalsotra
95	Chaitali Misra	Overexpression of a non-muscle RBFOX2 splice isoform induce cardiac arrhythmias in Myotonic Dystrophy	Auinash Kalsotra
11	Sushant Bangru	Temporal control of ESRP2 licenses fetal-to-adult switch in alternative splicing required for hepatocyte maturation	Auinash Kalsotra
148	Ullas Valiya Chembazhi	Single-cell transcriptomics reveal distinct fetal like cellular states during murine liver regeneration	Auinash Kalsotra
7	Jowad Atway	Understanding the Novel Cleavage behavior of RNase Cusativin through Site-Specific Mutagenesis and Liquid Chromatography coupled with Mass Spectrometry	Balasubrahmanyam Addepalli
124	Arpita Saha	Functions of telomerase RNA (TR) core domains in its biogenesis and telomere maintenance in a medically relevant parasite, Trypanosoma brucei	Bibo Li
142	Andrew Sugarman	Structural Dynamics of HIV ESS2p RNA Element	Blanton Tolbert
75	Jeff Levengood	Strategies for utilizing NMR to gain insights into an intrinsically disordered domain of hnRNP A1	Blanton Tolbert
33	Catherine Douds	In vivo RNA structure prediction by motif constraining: an integrative approach	Catherine Douds
144	Matthew Tanner	mRNA splicing is a marker of molecular pathology and response to therapeutics in myotonic muscular dystrophy patients and mouse models	Charles Thornton
50	Sherrell Haney	Improving cell permeability of a ribosome targeting peptide as a potential antibiotic	Christine Chow
96	Alan Mlotkowski	Theoretical pKa calculations of modified purine nucleobases using explicit waters and a polarizable Ccontinuum model	Christine Chow
61	Evan Jones	Theoretical pKa determinations of modified nucleobases using an implicit-explicit solvation model	Christine Chow
5	Rolando Alvarado	Cytoplasmic recapping, a new epitranscriptomic modification targeting long non-coding RNA	Daniel Kiss
145	Trinh T Tat	High-resolution integrative analysis to define putative cytoplasmic RNA recapping sites in mammalian cells	Daniel L. Kiss
68	Safiya Khurshid	Modulation of insulin receptor alternative splicing to develop cancer therapeutics	Dawn Chandler
122	Sarah Rundell	Structure of bPNA triplex hybrid determined by x-ray crystallography	Dennis Bong
76	Yufeng Liang	Conformationally-sensitive cleavage of human telomere DNA via molecular recognition of the loop region	Dennis Bong
89	Shiqin Miao	Duplex Stem Replacement with bPNA+ Triplex Hybrid Stems Enables Reporting on Tertiary Interactions of Internal RNA Domains	Dennis Bong
171	Oliver Munyaradzi	Helical bPNA targeting U-rich RNA	Dennis Bong
167	Kejia Zhang	Deciphering the biological function of tRNA methyltransferase 1 (TRMT1) using mouse models	Dragony Fu
9	Armend Axhemi	Functional synergy between Rrp6p and Rrp44p in the nuclear exosome	Eckhard Jankowsky
150	Sarah Venus	Interactions with Vaccinia Virus K7 Protein Alter the Biochemical Activity of the DEAD-Box RNA Helicase DDX3X	Eckhard Jankowsky
137	Sukanya Srinivasan	Auxiliary domains of the mammalian DEAH/RHA helicase DHX36 work in concert with the helicase core domains to remodel RNA structures.	Eckhard Jankowsky
26	Sara Cloutier	Genome-wide analysis of R-loops and nascent transcript synthesis in S. cerevisiae	Elizabeth Tran
93	Youssef Hegazy	Characterization of R-loop structures in budding yeast	Elizabeth Tran
25	Matthew Russon	Characterizing the Role of the DEAD-Box RNA helicase DDX5 in Small Cell Lung Cancer	Elizabeth Tran
51	Jordan Hartung	Toehold Mediated Shape Transition of Nucleic Acid Nanoparticles	Emil Khisamutdinov
172	Taylor Dodson	Quantitative analysis of post-transcriptional modifications from bacterial systems	Erin Prestwich
157	Ciara Witt	Using deep learning networks to solve the RNA design problem	Frank Aaron
30	Indrajit Deb	Insights into RNA recognition of small molecules using the Fragment Molecular Orbital (FMO) method	Frank Aaron
78	Eviania Likos	Androgen Receptor messenger RNA Metabolism	Girish Shukla
15	Asmita Bhattarai	Hsa-miR-149 Mediated Posttransriptional Control of Steroid Biosynthesis Pathway in Prostate Cancer	Girish Shukla
126	Manu Sanjeev	Role of SR proteins in mRNP packaging and Nonsense Mediated Decay	Guramrit Singh
1	Fuad Abbas	Developing an optimal AID-degron system to elucidate UPF protein function in human cells	Guramrit Singh
48	Prabesh Gyawali	A Single Molecule Study of the Impact of Small Molecules on Intermolecular G-Quadruplex Formation	Hamza Balci
102	Golam Mustafa	Short looped DNA as a Force Transducer: Conversion of single molecule FRET signal into force information	Hamza Balci
115	Suba Rajendren	Molecular Mechanisms to Regulate RNA Editing in nervous system	Heather Hundley
112	Reshma Raghava Kurup	Gene regulatory role of ADAR3 in Glioblastoma	Heather Hundley
101	Priyanka Mukherjee	Why do Glioblastomas require the non-functional deaminase ADAR3?	Heather Hundley
141	Halle Stump	Exploring the role of adr-2 in the innate immune response of C. elegans	Heather Hundley
81	Justin Mabin	Diversity and plasticity of human spliceosomal small nuclear RNA variants	Heidi Dvinge
110	Katelyn Perroz	Limited proteolysis of a DEAD-Box protein reveals small conformational changes	Ivelitza Garcia
143	Kathryn Sutter	Comparative Analysis of ATP Dissociation from Rok1p Variants of in the presence of RNA	Ivelitza Garcia
31	Amanda DiLoreto	Kinetic Analysis of ATP Dissociation from wt-Rok1p and its truncated variants	Ivelitza Garcia
117	Michelle Raymond	Structural characterization of DEAD-Box protein peripheral domains	Ivelitza Garcia
60	Ben Jepson	Understanding the biological significance of multiple zebrafish Trm10 homologs	Jane Jackman
59	Malithi Jayasinghe	Reverse (3'-5') RNA polymerases: Applications beyond tRNAHis maturation and non-coding RNA processing	Jane Jackman
119	Tracy Roach	Title not published online	Jane Jackman
32	Samantha Dodbele	Investigation into the function and mechanism of an orphan 3’-5’ polymerase implicated in noncoding RNA processing.	Jane Jackman
14	Mohammed Husain Bharmal	Probing determinants of translation initiation in non-SD mRNAs	Jared Schrader
6	James Aretakis	Exploring the global determinants of bacterial mRNA decay	Jared Schrader
4	Ali Aldhumani	RNA drug discovery: developing computational models to predict ‘hit’ compounds	Jennifer Hines
56	Md Ismail Hossain	Modulation of T-box riboswitch function by analogs of 4,5-disubstituted oxazolidinones	Jennifer Hines
127	Jens Schmidt	Mechanism of processive telomerase catalysis revealed by high-resolution optical tweezers	Jens Schimidt
71	Charlotte Kunkler	Stability of RNA•DNA-DNA triple helices depends on base triple composition and length of the RNA strand	Jessica Brown
20	Kurtis Breger	Elucidating the Kinetic Mechanism of Human METTL16	Jessica Brown
86	Phillip McCown	Title not published online	Jessica Brown
3	Christina Akirtava	Quantitative analysis of yeast Kozak variants for AUG and near-AUG start codons using a massively parallel reporter assay	Joel McManus
64	Murat C. Kalem	Post-transcriptional regulation of caspofungin resistance in Cryptococcus neoformans.	John Panepinto
39	Fiona Fitzgerald	Investigating the role of the DEAD-box helicase Drs1 in assembly of pre-60S subunits in Saccharomyces cerevisiae	John Woolford
155	Daniel Wilson	Maintenance of the polypeptide exit tunnel marks a nucleoplasmic checkpoint in large ribosomal subunit assembly	John Woolford
132	Gabriel Silveira dAlmeida	Overcoming a “molecular ruler” mechanism: the unusual heterotrimeric tRNA splicing endonuclease of Trypanosoma brucei	Juan Alfonzo
24	Luyi Cheng	A mechanistic study of the pbuE adenine riboswitch from the perspective of cotranscriptional chemical probing	Julius Lucks
12	Katherine Berman	Cotranscriptional RNA strand invasion mediates ligand sensing in the E. coli thiB thiamine pyrophosphate riboswitch	Julius Lucks
164	Angela Yu	Title not published online	Julius Lucks
37	Molly Evans	Maximizing quantitative structural information from high-throughput RNA structure probing	Julius Lucks
140	Eric Strobel	A ligand gated strand displacement mechanism for ZTP riboswitch transcription control	Julius Lucks
162	Mengkun Yang	Tetrahelical monomolecular architecture of nucleic acids probed by NMR	Karin Musier-Forsyth
22	Jun-Kyu Byun	Role of Unique C-terminal Domain in a Plant Aminoacyl-tRNA Trans-editing Protein	Karin Musier-Forsyth
18	Elaina Boyle	Title not published online	Karin Musier-Forsyth
107	Chathuri Pathirage	Investigating the effect of post translational modifications of LysRS on HIV-1 gRNA binding	Karin Musier-Forsyth
80	Levan Lomidze	Stability factors of monomolecular DNA and RNA quadruplexes	Karin Musier-Forsyth
91	Savannah Mills	Contribution of mRNA 3’ UTRs in substrate recognition by the nonsense-mediated mRNA decay pathway	Kristian Baker
113	Hamza Rahman	Purification and analysis of proteins associated with nonsense codon-containing mRNA in Saccharomyces cerevisiae	Kristian Baker
40	Monika Franco	Pseudouridinylation of mRNA coding sequences alters translation	Kristin Koutmou
62	Joshua Jones	Title not published online	Kristin Koutmou
90	Luke Miller	Development of novel tools to characterize mRNA chemical modifications	Kristin Koutmou
98	Jeremy Monroe	Translation is altered by the presence of N1-methylpseudouridine and 7-methylguanosine in mRNA coding regions	Kristin Koutmou
121	Bappaditya Roy	Global analysis of protein synthesis in Flavobacterium johnsoniae reveals the use of Kozak-like sequences in diverse bacteria	Kurt Fredrick
47	Michelle Gibbs	Functional analysis of BipA in E. coli reveals the plasticity of 50S ribosome assembly	Kurt Fredrick
23	Menglin Chen	Measures of single- versus multiple-round translation argue against a mechanism to ensure coupling of transcription and translation	Kurt Fredrick
87	Zakkary McNutt	Investigating the role of the Anti-Shine Dalgarno in the Bacteroidetes	Kurt Fredrick
35	Ashutosh Dubey	The RESC protein, MRB800 plays an important role in RNA editing progression by stabilizing protein-RNA and protein-protein interactions in Trypanosoma brucei	Laurie Read
94	Amartya Mishra	Modulation of RNA Editing Helicase 1 level regulates RNA editing profile of mitochondrial transcripts in trypanosomes	Laurie Read
135	Joseph Smith Jr.	Two distinct mechanisms of CYb and COIII mRNA editing regulation in Trypanosoma brucei	Laurie Read
134	Tyler Smith	Mechanistic framework for understanding ribosome sliding on homopolymeric A stretches	Markos Koutmos
136	Sarah Spigelmyer	Identification of the enzyme responsible for the acp3U modification in bacteria	Michael Guy
129	Nick Sebree	Identification of plant TRMT1 genes using fluorescent primer extension in yeast	Michael Guy
99	Rachel Morgeson	Identification of the methyltransferase responsible for 2’-O-methylation of tRNA residue 39 in plants	Michael Guy
65	Michael Kearse	Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors	Michael Kearse
153	Rebecca Wegman	Dissecting the role of protein arginine methylation on translation initiation factor eIF1A	Michael Yu
111	Anu Puppala	Determinantion of recognition elements governing binding of human selenocysteine synthase (SepSecS) to its substrate tRNA	Miljan Simonovic
156	Ashlynn Winkler	Synthesis of a fluorescent cytidine analogue	Mina Sumita
163	Adam Litterst	Creating Super-Aptamers with Modified Nucleobases for Biosensor	Mina Sumita
118	Tristan Sanford	Optimization and Quantification of Biofilm Produced by Escherichia coli K12 for Selection of DNA Aptamers	Mina Sumita
158	Austin Woodard	SPR-SELEX: New Method to Determine DNA Aptamers that Targets E. coli for Biosensor	Mina Sumita
67	Kunal Khanna	A novel single molecule microscopy technique for extremely specific sensing of microRNAs with greater sensitivity	Nils Walter
154	Robb Welty	RNA structure and dynamics act as a gate keeper of 3’ alternative splicing	Nils Walter
169	Ruoxia Zhao	Deinococcus radiodurans Transfer RNA Modified Nucleosides are Minimally Impacted UV Radiation	Pat Limbach
63	Manasses Jora	Pushing the boundaries of ribonucleoside detection and discovery by liquid chromatography-tandem mass spectrometry (LC-MS/MS)	Pat Limbach
46	Prabar Ghosh	3′UTR-mediated localization of mRNAs to the rear of migrating aortic endothelial cells	Paul Fox
66	Krishnendu Khan	Title not published online	Paul Fox
77	Katie Lichtenthal	Determining the mechanism of cooperative binding of trp to TRAP using Bacillus halodurans	Paul Gollnick
152	Melissa Ward	Nuclear speckle protein SON's role in transcription regulation at an inducible reporter gene array	Paula Bubulya
160	Congcong Xu	Title not published online	Peixuan Guo
151	Hongzhi Wang	Title not published online	Peixuan Guo
34	Lili Du	Arrowtail RNA for Ligand Display on Ginger derived Exosome-like Nanovesicles to deliver siRNA for Cancer Suppression	Peixuan Guo
170	Lixia Zhou	Title not published online	Peixuan Guo
168	Long Zhang	Title not published online	Peixuan Guo
159	Jiangbin Wu	EPRS Is a Critical Translational Control Factor in Cardiac Fibrosis	Peng Yao
84	Fatimah Matalkah	A glance at the role of KHDRBS3 in the tumorigenesis of TNBC	Peter Stoilov
131	Jacob Sieg	LC-MS identification of riboswitch ligands	Phil Bevilacqua
88	McCauley Meyer	Nucleotide level resolution of RNA folding interactions within peptide-based complex coacervates	Phil Bevilacqua
36	Glenn Duncan	Title not published online	Phil Bevilacqua
100	Matthew Mouck	Computational Discovery of Riboswitches in the Human Microbiom	Phil Bevilacqua
57	Ruochuan Huang	Effects of cellular concentrations of nucleotide diphosphate-chelated Mg2+ on RNA and DNA enzymes	Phil Bevilacqua
17	Kathryn Bormes	Role of Upstream RNA Secondary Structures in an RNA Thermometer from Bradyrhizobium japonicum	Phil Bevilacqua
10	Jared Baisden	A transient RNA protonation state modulates oncogenic microRNA-21 maturation	Qi Zhang
28	Kyle Crocker	A quantitative model of temperature actuated DNA origami nanocaliper constructs	Ralf Bundschuh
130	Elan Shatoff	Title not published online	Ralf Bundschuh
108	Robert Patton	Chemical crosslinking enhances RNA immunoprecipitation for efficient identification of binding sites of proteins that photo-crosslink poorly with RNA	Ralf Bundschuh
73	Richard A. Lease	Stem-loop Antisense RNA and DNA Exclude Mismatched Target Sequences	Richard Lease
147	Elizabeth Traverse	Stem-loop antisense RNA and DNA exclude mismatched target sequences	Richard Lease
29	Noah Daniels	Investigating the Role of DDX41 in pre-messenger RNA Splicing and Leukemogenesis	Richard Padgett
53	Courtney Hershberger	Complex landscape of splicing signatures in myeloid neoplasms	Richard Padgett
133	Jagjit Singh	Modeling microcephaly in patient iPS cell-derived brain organoids with U4atac snRNA mutations	Richard Padgett
42	Varun Gadkari	Characterizing FMN-analogs binding the FMN riboswitch by native ion mobility-mass spectrometry	Ruotolo Brandon
43	Tyler Galbraith	Lethal Mutation in 16S rRNA cause defects in RNA Chaperone Activity of RsmC	Sanjaya Abeysirigunawardena
97	Mohamed Rushdhi Mohamed Rauff	Title not published online	Sanjaya Abeysirigunawardena
2	Sudeshi Madushani Abedeera	Title not published online	Sanjaya Abeysirigunawardena
45	Keshav Gc	Moonlighting of RsmC as RNA chaperone and annealer protein	Sanjaya Abeysirigunawardena
58	Kumudie Jayalath	Pseudouridylation enzyme RsuA binding and its activity is modulated by ribosomal proteins and local rRNA structures	Sanjaya Abeysirigunawardena
146	Minhchau To	S4-like domain regulates binding of RsuA to 16S rRNA	Sanjaya Abeysirigunawardena
128	Stefani Schmocker	Title not published online	Sanjaya Abeysirigunawardena
166	Huaqun Zhang	Folding Mechanism of An RNA Thermosensor from Listeria Monocytogenes	Sarah Keane
49	Ian Hall	Interactions of structured regulatory RNAs	Sarah Keane
125	Ansuman Sahoo	Dynamic phosphorylation of yeast eIF4A drives changes in gene expression that couple protein synthesis with cell division	Sarah Walker
139	Rajneesh Srivastava	Functional annotation of the human protein-RNA interaction network via transcriptome-wide pooled CRISPR/Cas9 screens to edit the RBP binding sites	Sarath Janga
138	Mansi Srivastava	Transcriptome-wide high-throughput mapping of protein-RNA occupancy profiles using an integrated phase separation and crosslinking approach	Sarath Janga
92	Quoseena Mir	Identification of splice isoforms in T helper (Th) cells using Nanopore-based cDNA sequencing	Sarath Janga
41	Gayathri Panangipalli	Maternal THC exposure leads to large-scale downregulation of genes in pre-frontal cortex of developing mouse brain	Sarath Janga
69	Alexander Krohannon	CASowary: a tool for systematic design and optimization of cas13 guide RNAs to facilitate disrupting mRNA function	Sarath Janga
82	Monica Mannings	Pnrc2 promotes 3'UTR-dependent oscillatory transcript decay during vertebrate segmentation	Sharon Amacher
55	Mohammed Enamul Hoque	piRNA mediated dual gene knockdown via the ping-pong mechanism	Soumitra Basu
116	Chad Ratterman	Branchpoint identity and branch length effects on lariat debranching enzyme activity	Subha R. Das
123	Alex Runyon	Importance of conserved elements in the Bacillus subtilis thrS T-box riboswitch	Tina Henkin
13	Divyaa Bhagdikar	Comparative analysis of translational and transcriptional S-box riboswitches	Tina Henkin
165	Walter Zahurancik	Use of single-molecule fluorescence co-localization spectroscopy to study archaeal RNase P assembly	Venkat Gopalan
72	Stella Lai	A Tale of Two Types of Archaeal RNase P: Of Rate-Limiting Steps and Subunit Stoichiometries	Venkat Gopalan
19	Rachel Braun	Assessing the utility of a novel fluorescence turn-on assay for RNase P	Venkat Gopalan
83	Ila Marathe	Use of FRET and SHAPE-Seq to elucidate structure-function relationships in archaeal RNase P, a multi-subunit catalytic ribonucleoprotein	Venkat Gopalan
114	Swetha Rajasekaran	Pumilio-mediated post-transcriptional regulation of Dicer1	Wayne Miles
106	Rahi Patel	Title not published online	Wayne Miles
70	Jan Kucinski	RNase H1 is required for Arabidopsis thaliana embryonic development	Wierzbicki Andrzej
27	Adriana Coke	Role of Exonucleases in RNA Polymerase V Transcript Degradation	Wierzbicki Andrzej
21	Audrey Bui	Title not published online	Xiao-Ning Zhang